2020 Obesity Webinar Series 2 - Utilizing Stable Isotope Tracers In Preclinical Models Of Obesity

Stable isotope analysis is a powerful tool for obesity research. Nutrients labeled with these tracers are nontoxic to animal models and can be continuously tracked in vivo. In this webinar, Marshall McCue, PhD, will review stable isotope biochemistry, standard nomenclature, unit conversions and simple calculations. In addition, he will present case studies highlighting the use of novel laser-based stable isotope approaches to track 13C-labeled nutrient oxidation second-by-second in real-time. McCue will discuss how dietary (exogenous) and stored (endogenous) nutrients can be traced to identify several research questions, including how to tell if your animal is snacking on cached food and how do experimental manipulations alter oxidation of stored lipids.