Osteoporosis is one of the most common degenerative diseases of aging. Half of adult women and one-quarter of adult men will develop an osteoporosis-related fracture. Current approaches for treating osteoporosis can lower the risk of fracture, but there is no cure. In this webinar, Joy Wu, MD, PhD of Stanford University in California, will review the pathophysiology of bone loss with aging, focusing on the imbalance between bone formation by osteoblasts and bone resorption by osteoclasts. She will discuss stem cell sources of osteoblasts, anabolic signaling pathways and targeting inflammation and senescence. Key learning objectives include: describing how bone formation and resorption are coupled and regulate bone mass, exploring factors that contribute to aging-related bone loss, and discussing benefits and limitations of current osteoporosis therapies.