2021 Translational Discovery Series 3-Old Dogs Benefit from New Tricks: 3D Analysis of Arterial Injury to Study Nrf2 Dependent Inhibition of Neointimal Hyperplasia in Rats

Professor Edward Bahnson describes a traditional rat carotid balloon injury model to study arterial restenosis and presents a novel methodological approach involving 3D imaging of vascular injury models.

Highlights include:

*How nuclear factor-erythroid factor 2-related factor 2 (Nrf2) affects the redox status of cells

*The effects of cinnamic aldehyde treatment on Nrf2

*Evidence for a Nrf2-dependent mechanism of neointimal hyperplasia inhibition by cinnamic   aldehyde treatment

*Benefits of 3D analysis of arterial injury over traditional 2D histology analysis