Understanding preclinical modeling for cancer cells may optimize the translation of in vitro findings into clinical use but is limited by the inability to reproducibly propagate primary specimens ex vivo. During this webinar, Johannes Waldschmidt, MD, and Andreas Thomsen, MD, of the University of Freiburg in Germany, will discuss a 3D co-culture platform for the propagation of primary multiple myeloma cells ex vivo. Webinar topics will include how 3D models may substitute conventional testing systems, how these models open a new framework for the in vitro assessment of drug resistance in cancer; and how they allow for more accurate prediction of active drug compounds to reduce time and financial expenses for drug discovery at the earliest stage possible.